CD31/PECAM-1 Rabbit Monoclonal Antibody-BS9921M

CD31/PECAM-1 Rabbit Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9921M-50, BS9921M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P16284

Host: Rabbit

Reactivity: Human

Applications: WB, IHC FC

All Applications: WB: 1:1000-1:2000
IHC: 1:50-1:200
FC: 1:50-1:100

Background: CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.

Purification and Purity: Protein A affinity purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of CD31 and does not cross-react with related proteins.

Bioworld Molecular Weight: ~ 130 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CD31/PECAM-1 Rabbit mAb at 1:1000 dilution
Lane 1: THP-1 whole cell lysate, Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD31 antibody.Counter stained with hematoxylin.

Alternative Name: Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1

Immunogen: Recombinant antibody.

Conjugate: Unconjugated

Modification: Unmodified