Product Description

CD317 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0356P-50, NCP0356P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: BST2 (CD317, Tetherin, HM1.24) is a type II transmembrane glycoprotein functioning as a major mediator of the innate immune defense against the dissemination of enveloped viruses by tethering virion on the cell surface. BST2 has an N-terminal cytoplasmic tail for endocytosis and cytoskeletal signaling, a transmembrane domain, an extracellμlar domain containing putative disμlfide bonds and coiled coil region for forming homodimer, and a C-terminal GPI domain for membrane anchoring. Both the transmembrane domain and the GPI domain can insert either to the cell membrane or the viral envelope membrane and hold them together to prevent viral release. Some viruses encode proteins, such as HIV-1 and Vpu respectively, to act as antagonists to counteract BST2. BST2 is overexpressed in gastrointestinal cancers, breast cancer, lung cancer, and mμltiple myeloma. BST2 monoclonal antibody targeting myeloma or lung cancer cells induces cellμlar cytotoxicity and cell death (ADCC, antibody-dependent cell-mediated cytotoxicity). Thus, BST2 serves as a potential target for tumor immunotherapy.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: Bone marrow stromal antigen 2, BST-2, HM1.24 antigen, Tetherin, CD317, BST2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD317.

Dilution: WB: 1:5000~1:10000
IF: 1:100~1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD317 polyclonal antibody detects endogenous levels of CD317 protein.

Molecular Weight: ~ 30/60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q10589

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only