Product Description

CD32-C Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA23045-50, RA23045-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: caution:Has sometimes been attributed to correspond to FcR-IIB., caution:Has sometimes been attributed to correspond to FcR-IIC., disease:A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t (1;22) (q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression., domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases., domain:Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation., function:Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells., function:Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., subunit:Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1., tissue specificity:Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells., tissue specificity:Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: FCGR2C, CD32, FCG2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-c, IgG Fc receptor II-c, CDw32, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, CD antigen CD32

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 35

Protein Molecular Weight (kDa): 35

Storage: -20°C/1 year

Human Gene ID: 9103

Human SwissProt Number: P31995

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only