CD34 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65854-50, BS65854-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecμle with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellμlar matrix or directly to stromal cells. It coμld act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellμlar chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB Alternate Names: CD34 antigen, CD34 molecμle, Cluster designation 34, Hematopoietic progenitor cell antigen CD34, HPCA1, CD34_HUMAN, Hematopoietic Stem Cell Marker, Endothelial Markers, Tumor biomarkers. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from human CD34:201-300/382 Dilution: WB=1:500-2000 Purification: affinity purified by Protein A Specificity: CD34 Polyclonal Antibody detects endogenous levels of CD34 protein. Molecular Weight: ~120 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles. SwissProt: Q64314 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only