CD35 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA23047-50, RA23047-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: complement C3b/C4b receptor 1 (Knops blood group) (CR1) Homo sapiens This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, ELISA Alternate Names: complement component (3b/4b) receptor 1/2 (Knops blood group) Clonality: Polyclonal Dilution: WB 1:500-2000, ELISA 1:10000-20000 Molecular Weight: 220 Protein Molecular Weight (kDa): 220 Storage: -20°C/1 year Human Gene ID: 1378 Human SwissProt Number: P17927/Q2VPA4 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only