CD35 rabbit pAb - ES8467

CD35 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8467-50, ES8467-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants

Alternate Name: complement component (3b/4b) receptor 1/2 (Knops blood group)

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CR1/CR1L. AA range:300-350 & 740-790

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 220kD

Human Gene ID: 1378

Human SWISS Prot NO: P17927/Q2VPA4

Subcellular Location: Membrane; Single-pass type I membrane protein.

Research Use Only