Product Description

CD3e Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66827-50, MB66827-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellμlar signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a mμltisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (CD3-g and CD3-e), a heterodimer of d and e chains (CD3-d and CD3-e) and a homodimer of two z chains (CD3-z) or a heterodimer of z and h chains (CD3-z and CD3-h). CD3-z and CD3-h are encoded by the same gene, but differ in their carboxyl-terminal ends due to an alternative splicing event. CD3-g, CD3-e and CD3-d each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, CD3-z contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regμlating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to CD3-z ITAMs has been solved.

Category: Primary Antibody

Reactivity: Mouse

Host: Mouse

Applications: WB

Alternate Names: T3E, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide of human CD3e. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of CD3e protein.

Molecular Weight: ~ 26 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22646

Product: Mouse IgG2a. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only