Product Description

CD3G Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60356-50, BS60356-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The T cell antigen receptor (TCR) recognizesforeign antigens and translates such recognition eventsinto intracellμlarsignalsthat elicit a change in the cell froma dormant to an activated state.Much of this signaling processcan be attributed to a mμltisubunitcomplex of proteins that associates directly with the TCR. Thiscomplex has been designated CD3 (cluster of differentiation 3). It iscomposed of five invariant polypeptide chainsthat associate to form three dimers: a heterodimer of γ and ε chains(γε), a heterodimer of δ and ε chains(δε) and a homodimer of two ζ chains(ζζ) or a heterodimer of ζ and η chains(ζη). The ζ and η chains are encoded bythe same gene but differ in theircarboxyl-terminal ends due to an alternative splicing event. The γ, ε and δ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activationmotif (ITAM). In contrast, the ζ chain containsthree consecutive copies of the same motif. Phosphorylated ITAMs act as docking sitesfor protein kinases such as ZAP-70 and Syk and are also capable of regμlating theirkinase activity. The crystalstructure of ZAP-70’s SH2 domains bound to the ζ chain ITAMs has been solved.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G, T3G, CD3-γ, CD3 γ, CD3γ

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human CD3G.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD3G polyclonal antibody detects endogenous levels of CD3G protein.

Molecular Weight: ~ 20 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P09693

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only