Product Description

CD40 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66945-50, MB66945-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD40, also known as tumor necrosis factor receptor superfamily member 5 (TNFRSF5), is a type I transmembrane protein expressed on the surface of B cells and professional antigen-presenting cells of the immune system, as well as on several non-hematopoietic cell types and cancers . CD40 interacts with CD40 ligand (CD40L/TNFSF5), which is expressed primarily on activated T cells but has also been reported on blood platelets, mast cells, basophils, NK cells, and B cells . Upon engagement with CD40L, CD40 signals through TNF receptor associated factors and MAP kinase signaling pathways, resμlting in a wide variety of immune and inflammatory responses, including dendritic cell activation and cross-presentation, T cell-dependent immunoglobμlin class switching, memory B cell development, and germinal center formation . The CD40/CD40L axis is essential for the initiation and progression of cellμlar and humoral adaptive immunity, and is an important area of interest in the study of tumor immunology, neurodegenerative diseases, vascμlar diseases, and inflammatory disorders.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: TNFRSF5, Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD40. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of CD40 protein.

Molecular Weight: ~ 31 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P25942

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only