CD40 Monoclonal Antibody
Size: 50μL, 100μL
Catalogue Numbers: RA10933-50, RA10933-100
Citations, Manuals and MSDS Available upon request.
Background: CD40 molecule (CD40) Homo sapiens This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG
Condition: Purified recombinant fragment of CD40 expressed in E. Coli.
Storage Instructions: -20°C/1 year
Applications: IF/ICC; ELISA
Species Cross-Reactivity: Human
GeneID (Human): 958
SWISS: P25942
Source: Mouse
Research Use Only