CD42c rabbit pAb - ES8786

CD42c rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8786-50, ES8786-100

Citations, Manuals and MSDS Available upon request.

Background: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, t

Alternate Name: Platelet glycoprotein Ib beta chain (GP-Ib beta; GPIb-beta; GPIbB; Antigen CD42b-beta; CD antigen CD42c)

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthetic peptide from human protein at AA range: 90-150

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 2812

Human SWISS Prot NO: P13224

Subcellular Location: Membrane; Single-pass type I membrane protein.

Research Use Only