Product Description

CD45 (8C1) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3167-50, MB3167-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P06800

Host: Mouse

Reactivity: Human

Applications: WB, IHC-F, IHC-P, ICC/IF

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG1

Bioworld Molecular Weight: Calculated MW: 145 kDa; Observed MW: 145 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunofluorescence analysis of CD45 in Human livercancer tissue using CD45 antibody, and DAPI., Immunohistochemical analysis of paraffin-embedded Human tonsils using CD45 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Negative control was used by secondary antibody only., Western blot analysis of CD45 in Jurkat lysates using CD45 antibody.

Alternative Name: GP180; L CA; CD45 antigen

Immunogen: Synthetic Peptide of CD45

Conjugate: Unconjugated

Modification: Unmodified