Product Description

CD6 Recombinant Protein

Sizes: 500μg, 1mg

Catalogue Numbers: NCP0218-500, NCP0218-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: T cell differentiation antigen CD6 is a cell adhesion molecμle expressed on immature thymocytes and mature T cells, and has also been detected on a subset of B cells and NK cells within the immune system. CD6 mediates cell-cell interactions through it’s binding partner CD166/ALCAM, and contributes to the formation and maturation of the immunological synapse. CD6 functions as a co-stimμlatory receptor, promoting T cell activation and proliferation through the TCR/CD3 complex signaling cascade. Studies have shown CD6 can be glycosylated, hyperphosphorylated on serine and threonine residues, and phosphorylated on tyrosine residues, each of which can differentially effect the function and signaling of this molecμle. CD6 also functions as a calcium-dependent pattern receptor that binds and aggregates Gram-positive and Gram-negative bacteria. In response to lipopolysaccharide, CD6 mediates activation of the inflammatory response and secretion of pro-inflammatory cytokines.

Category: Protein

Host: E. coli

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Molecular Weight: ~44kDa

Solubility: PBS, 4M Urea, PH7.4

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restriction Sites: NdeI-XhoI

SwissProt: P30203

Tag: His-tag

Amino Acid Sequence: CATCCGAGTCCGGCACCGCCTGATCAGCTGAATACCAGCAGCGCAGAAAGTGAACTGTGGGAACCGGGTGAACGTCTGCCGGTGCGCCTGACCAATGGCAGCAGCAGTTGCAGCGGCACCGTGGAAGTGCGCCTGGAAGCAAGTTGGGAACCGGCATGCGGTGCCCTGTGGGATAGCCGTGCAGCCGAAGCCGTGTGCCGCGCACTGGGTTGTGGCGGTGCAGAAGCCGCCAGCCAGCTGGCACCGCCTACCCCTGAACTGCCGCCGCCTCCTGCCGCTGGTAATACCAGCGTTGCAGCAAATGCAACCCTGGCAGGCGCACCGGCACTGCTGTGCAGTGGCGCAGAATGGCGTCTGTGCGAAGTTGTTGAACATGCATGTCGCAGTGATGGTCGCCGTGCCCGCGTTACCTGTGCCGAAAATCGTGCCCTGCGTCTGGTGGATGGCGGTGGCGCATGCGCAGGTCGTGTTGAAATGCTGGAACATGGCGAATGGGGCAGTGTGTGTGATGATACCTGGGATCTGGAAGATGCACATGTTGTGTGTCGCCAGCTGGGCTGTGGCTGGGCCGTGCAAGCCCTGCCTGGTCTGCACTTCACCCCGGGTCGTGGCCCGATTCATCGCGATCAGGTTAATTGCAGCGGTGCAGAAGCATATCTGTGGGATTGTCCGGGTCTGCCGGGCCAGCATTATTGTGGCCATAAAGAAGATGCAGGTGCCGTGTGCAGTGAACATCAGAGCTGGCGTCTGACCGGTGGTGCCGATCGCTGCGAAGGCCAGGTTGAAGTTCACTTCCGCGGCGTGTGGAATACCGTGTGCGATAGCGAATGGTATCCGAGCGAAGCCAAAGTGCTGTGCCAGAGTCTGGGTTGCGGTACCGCCGTGGAACGTCCGAAAGGTCTGCCGCATAGTCTGAGTGGTCGCATGTATTATAGCTGTAATGGTGAAGAACTGACCCTGAGCAATTGTAGCTGGCGCTTCAATAATAGTAATCTGTGCAGCCAGAGTCTGGCCGCACGCGTTCTGTGCAGCGCCAGTCGCAGCCTGCATAATCTGAGTACCCCGGAAGTTCCGGCCAGTGTTCAGACCGTGACCATTGAAAGTAGTGTGACCGTTAAAATTGAAAATAAGGAAAGCCGCGAACTGATGCTG

Expression Vector: pet-22b(+)

Research Use Only