Product Description

CD70 Polyclonal Antibody

Catalogue Numbers: NCP0224P-50, NCP0224P-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: P32970

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1:2000~1:5000

Background: CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is normally expressed on medullary thymic epithelial cells. Its expression is induced on activated lymphoid cells (B cells, T cells, and NK cells) and dendritic cells. CD70 is a ligand for CD27, a co-stimulatory receptor that plays an important role in T cell activation and proliferation. CD70 overexpression has been reported in various tumors such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma and it’s being actively pursued as a therapeutic target.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD70 polyclonal antibody detects endogenous levels of CD70 protein.

Extra Notes: Western blot (WB) analysis of CD70 polyclonal antibody at 1:2000 dilution
Lane1:EC9706 whole cell lysate(30ug)
Lane2:MCF-7 whole cell lysate(30ug)
Lane3:CT-26 whole cell lysate(30ug)

Bioworld Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD70; CD27L; CD27LG; TNFSF7

Immunogen: Recombinant protein of human CD70.

Conjugate: Unconjugated

Modification: Unmodified