Product Description

CD71 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66783-50, MB66783-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disμlfide-linked homodimer of two identical subunits. CD71 binds to two molecμles of transferrin and a serum iron-transport protein, and directs the cellμlar uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticμlocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregμlated upon activation of lymphocytes, monocytes and macro-phages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene resμlt in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD71. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of CD71 protein.

Molecular Weight: ~ 101 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02786

Product: Mouse IgM. Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only