Product Description

CD82  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0231P-50, NCP0231P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD82 (KAI1) belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellμlar domain (ECL1), and one long extracellμlar domain (ECL2). CD82 does not have enzymatic activity and appears to function by regμlating the trafficking of other proteins and organization of the cell membrane. CD82 was originally described as a costimμlator for T cells that directly associates with CD4 and CD8, and was subsequently identified during a screen as a metastasis suppressor in prostate cancer. CD82 has since been found to act as a metastasis suppressor in a variety of cancers, and its downregμlation is associated with poor prognosis in research studies. CD82 suppresses metastasis through mμltiple mechanisms including inhibition of cell motility and invasion by modμlating c-Met and the urokinase plasminogen activator surface receptor (uPAR), as well as promotion of homotypic cell-cell adhesion by stabilizing interactions between E-cadherin and β-catenin.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IF

Alternate Names: CD82 antigen, C33 antigen, C33 antigen, Inducible membrane protein R2, Metastasis suppressor Kangai-1, Suppressor of tumorigenicity 6 protein, Tetraspanin-27 (Tspan-27), CD82

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD82.

Dilution: IF: 1:200~1:800

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD82 polyclonal antibody detects endogenous levels of CD82 protein.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P27701

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only