Product Description

CD83 (P130) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2204-50, BS2204-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD83 is a heavily glycosylated membrane protein of the immunoglobμlin (Ig) superfamily that is expressed in mature dendritic cells, Langerhans cells and interdigitating reticμlum cells within lymphoid tissues. Structurally, CD83 resembles other Ig superfamily members, which have an extracellμlar V-type Ig-like domain, a single transmembrane domain and a 40 residue cytoplasmic tail. CD83 expression is used as a marker for mature, antigen presenting dendritic cells that are capable of generating tumor-specific T cell immunity, a phenotype with implications as an anticancer vaccine. CD83-IgG1(fc) chimera studies indicate that CD83 is a sialic acid-binding, Ig-like lectin (Siglec) adhesion molecμle that is involved in cell adhesion/signaling by hosting dendritic cell interactions with monocytes and CD8+ T cells..

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15, CD83

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human CD83.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD83 (P130) polyclonal antibody detects endogenous levels of CD83 protein.

Molecular Weight: ~ 23, 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01151

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only