Product Description

CD84 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0336P-50, NCP0336P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Self-ligand receptor of the signaling lymphocytic activation molecμle (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modμlating the activation and differentiation of a wide variety of immune cells and thus are involved in the regμlation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimμlation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicμlar helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regμlates high affinity immunoglobμlin epsilon receptor signaling, independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modμlates LPS-induced cytokine secretion, involving ITSM 2 (By similarity). Positively regμlates macroautophagy in primary dendritic cells via stabilization of IRF8, inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecμle 5, CD_antigen: CD84, CD84, SLAMF5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human CD84.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD84 polyclonal antibody detects endogenous levels of CD84 protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UIB8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only