Product Description

CD8A  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0234P-50, NCP0234P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integral membrane glycoprotein that plays an essential role in the immune response and serves mμltiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecμle:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellμlar proteins. Interacts simμltaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellμlar signaling pathways by phosphorylating various substratesμltimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of mμltiple target cells. CD8A homodimer molecμles also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IF

Alternate Names: T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD8A.

Dilution: IF: 1:100~1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD8A polyclonal antibody detects endogenous levels of CD8A protein.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01732

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only