CDH23 Polyclonal Antibody
Catalogue Numbers: BS60676-50, BS60676-100
Sizes: 50µl, 100µl
Alternative Name: Cadherin-23; Otocadherin; CDH23; KIAA1774; KIAA1812; UNQ1894; PRO4340
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9H251
Host: Rabbit
Reactivity: Human
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Cadherin-23 represents the first in this family of calcium binding proteins of which mutations in the extracellular calcium binding domain contribute to an inherited disorder, Usher syndrome type 1D (USH1D). Patients with USH1D exhibit congenital sensorineural hearing loss, vestibular dysfunction, and visual impairment due to early onset of retinitis pigmentosa (RP). In the inner ear, cadherin-23 interacts with myosin VIIIa and harmonin to form a functional network duing hair cell differentiation, and in the retina to assemble a supra-molecular complex contributing to the organization of the cytoskeletal matrices of the pre- and post-synaptic region. A number of cadherin-23 splice variants exist in association with various phenotypic expression, indicating that differential mutations result in variable presentation of the disease.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CDH23 polyclonal antibody detects endogenous levels of CDH23 protein.
Bioworld Molecular Weight: ~ 59 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of CDH23 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human CDH23
Conjugate: Unconjugated
Modification: Unmodified