Product Description

Cdk4 Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10957-50, RA10957-100

Citations, Manuals and MSDS Available upon request.

Background: cyclin dependent kinase 4 (CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat; Dog; Pig

GeneID (Human): 1019

SWISS: P11802

Source: Mouse

Research Use Only