Product Description

CDK5R1 (Q31) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2065-50, BS2065-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cyclin dependent kinase-5 (Cdk5), a key regμlator of cell cycle progression, was originally isolated on the basis of its structural homology to Cdc2, a wellcharacterized regμlator of cell cycle progression. Although Cdk5 is expressed at the highest level in the brain of adμlt mice, intermediate levels in testis and low or undetectable levels in all other tissues, brain is the only tissue from which Cdk5 can be isolated as an active kinase. These findings may be explained by the cloning and characterization of a Cdk5 regμlatory subunit, designated p35. p35 displays a neuronal cell-specific pattern of expression, physically associates with Cdk5 and activates Cdk5 enzymatic activity. p35 is also expressed in many tissues in a truncated form, designated p25.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regμlatory subunit 1, TPKII regμlatory subunit, Cyclin-dependent kinase 5 activator 1, p35, p35, CDK5R1, CDK5R, NCK5A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1-54 of Human p35.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CDK5R1 (Q31) polyclonal antibody detects endogenous levels of CDK5R1-p35 protein, and does not cross-react with CDK5R1-p25 protein.

Molecular Weight: ~ 35 kDa

Pathway: Dopamine Signaling in Parkinson's Disease Plathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15078

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only