CDK6 Polyclonal Antibody-BS90283

CDK6 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90283-50, BS90283-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q00534

Host: Rabbit

Reactivity: Human, Mouse, rat

Applications: WB, ICC IHC

All Applications: WB:1:2,000
ICC:1:200
IHC:1:200

Background: CDK6 protein contains a catalytic core composed of a serine/threonine domain.This protein also contains an ATP-binding pocket, inhibitory and activating phosphorylation sites, a PSTAIRE-like cyclin-binding domain and an activating T-loop motif. CDK6 is involved in a positive feedback loop that activates transcription factors through a reaction cascade. CDK6 is important for the control of G1 to S phase transition. However, in recent years, new evidence proved that the presence of CDK6 is not essential for proliferation in every cell type, the cell cycle has a complex circuitry of regulation and the role of CDK6 might be more important in certain cell types than in others, where CDK4 or CDK2 can act as protein kinases compensating its role.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CDK6 polyclonal antibody detects endogenous levels of CDK6 protein.

Bioworld Molecular Weight: 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CDK6 on different cell lysates using anti-CDK6 antibody at 1/2000 dilution.
Positive control:
Lane 1: K562
Lane 2: COS-1, ICC staining CDK6 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CDK6, CDK 6, CDK6, CDK6, Cell division protein kinase 6, Crk 2, Crk2, Cyclin dependent kinase 6, Cyclin-dependent kinase 6, MGC59692, p40, PLSTIRE, Serine/threonine protein kinase PLSTIRE, Serine/threonine-protein kinase PLSTIRE, STQTL11,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodified