Cdk8 Polyclonal Antibody-BS90286

Cdk8 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90286-50, BS90286-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49336(Human) Q8R3L8(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IP

All Applications: WB:1:1,000-1:2,000

Background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Large complexes containing Cdk8, cyclin C and the large subunit of RNA polymerase II have been identified. Cdk8 is thought to regulate RNA polymerase II function in conjunction with cyclin C. Cdk8 has been demonstrated to function as a transcriptional activator when fused to the DNA binding domain of GAL4.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cdk8 on NIH/3T3 cellsLysates using anti-Cdk8 antibody at 1/1,000 dilution.

Bioworld Molecular Weight: 53 kDa

Specificity: Cdk8 polyclonal antibody detects endogenous levels of Cdk8 protein.

Alternative Name: CDK8, cdk8, CDK8 protein kinase, CDK8, Cell Division Kinase 8, Cell division protein kinase 8, Cyclin Dependent kinase 8, Cyclin-dependent kinase 8, K35, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8, Protein kinase K35,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified