Product Description

CDKN2A/p16INK4a Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10721-50, MB10721-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P51480

Host: Rabbit

Reactivity: Mouse, Rat

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.CautionThe proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q64364) which is encoded by the same gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 18 kDa; Observed MW: 18 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CDKN2A/p16INK4a in 3T3 lysates using CDKN2A antibody., Western blot analysis of CDKN2A/p16INK4a in C6 lysates using CDKN2A/p16INK4a antibody.

Alternative Name: Cdkn2a; P16ink4a; Cyclin-dependent kinase 4 inhibitor A (CDK4I); p16-INK4a ; p16-INK4

Immunogen: Recombinant protein of mouse CDKN2A/p16INK4a

Conjugate: Unconjugated

Modification: Unmodified