CDKN2AIP Polyclonal Antibody - E-AB-10510

CDKN2AIP Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-10510-60, E-AB-10510-120, E-AB-10510-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CDKN2AIP

Target Synonym: Calcium response factor; CARF; CARF; CDKN2A interacting protein; CDKN2A-interacting protein; Cdkn2aip; collaborates/cooperates with ARF (alternate reading frame) protein; Collaborator of ARF; FLJ20036

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9NXV6

Background: CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

Concentration: 0.3 mg/mL

Immunogen: Recombinant protein of human CDKN2AIP

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only