Product Description

CDX2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90290-50, BS90290-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q99626(Human) Unigene:64495(Rat)

Host: Rabbit

Reactivity: Human, Rat, Rabbit

Applications: WB, ICC/IF, IHC, FC

All Applications: WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila 'caudal' gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis, and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CDX2 polyclonal antibody detects endogenous levels of CDX2 protein.

Bioworld Molecular Weight: 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CDX2 on AGS cells lysates using anti-CDX2 antibody at 1/1,000 dilution., ICC staining CDX2 in LOVO cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CDX2, Caudal type homeo box 2, Caudal type homeo box transcription factor 2, Caudal type homeobox 2, Caudal type homeobox protein 2, Caudal type homeobox transcription factor 2, Caudal-type homeobox protein 2, CDX 2, CDX 3, CDX-3, Cdx2, CDX2, CDX3, Homeobox protein CDX 2, Homeobox protein CDX-2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified