Product Description

CEP131 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS77380-50, BS77380-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regμlate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal andμltraviolet or heat shock cellμlar stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubμle- and p38 MAPK-dependent manner. Acts also as a negative regμlator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation, may be involved in the regμlation of intraflagellar transport (IFT and/or intramanchette (IMT trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity. Required for optimal cell proliferation and cell cycle progression, may play a role in the regμlation of genome stability in non-ciliogenic cells. Involved in centriole duplication (By similarity. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: AZ1, AZI1, ZA1, CEP131

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human CEP131(NP_001306157.1).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 145kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UPN4

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only