Product Description

CEP57 Polyclonal Antibody

Catalogue Numbers: BS65258-50, BS65258-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Swiss-Prot: Q86XR8

Host: Rabbit

Reactivity: Human

Applications: WB,ELISA

All Applications: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Background: centrosomal protein 57(CEP57) Homo sapiens This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.

Extra Notes: Western blot analysis of lysates from COLO and LOVO cells, using CEP57 Antibody. The lane on the right is blocked with the synthesized peptide.

Bioworld Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CEP57; KIAA0092; TSP57; Centrosomal protein of 57 kDa; Cep57; FGF2-interacting protein; Testis-specific protein 57; Translokin

Immunogen: The antiserum was produced against synthesized peptide derived from human CEP57. AA range:241-290

Conjugate: Unconjugated

Modification: Unmodified