Product Description

CERS4 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-13375-60, E-AB-13375-120, E-AB-13375-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CERS4

Target Synonym: ceramide synthase 4; CerS4; FLJ12089; LAG1 homolog ceramide synthase 4; LAG1 longevity assurance homolog 4; LAG1; S. cerevisiae; homolog of; 4; LASS 4; LASS4; LASS4 LAG1 homolog ceramide synthase 4; LASS4; TRAM homolog 1; Trh 1; Trh1

Research Areas: Cancer, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9HA82

Background: The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.

Concentration: 0.9 mg/mL

Immunogen: Synthetic peptide of human CERS4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW: 46kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only