Product Description

CFC1B/CFC1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60336-50, BS60336-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellμlar and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins. Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrμlation. Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects. Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pμlmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Cryptic family protein 1B, CFC1B

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human CFC1B/CFC1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CFC1B/CFC1 polyclonal antibody detects endogenous levels of CFC1B/CFC1 protein.

Molecular Weight: ~ 20 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P0CG36/P0CG37

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only