CFC1B/CFC1 Polyclonal Antibody-BS60336

CFC1B/CFC1 Polyclonal Antibody

Catalogue Numbers: BS60336-50, BS60336-100

Sizes: 50µl, 100µl

Alternative Name: Cryptic family protein 1B; CFC1B

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P0CG36/P0CG37

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellular and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins. Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrulation. Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects. Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CFC1B/CFC1 polyclonal antibody detects endogenous levels of CFC1B/CFC1 protein.

Bioworld Molecular Weight: ~ 20 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CFC1B/CFC1 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: H9C2 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CFC1B/CFC1.

Conjugate: Unconjugated

Modification: Unmodified