cGAS Monoclonal Antibody-MB67150

cGAS Monoclonal Antibody

Catalogue Numbers: MB67150-50, MB67150-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q8N884

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Cyclic GMP-AMP synthase (cGAS, MB21D1) is an antiviral enzyme that produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA. The cGAS protein acts as a cytosolic DNA sensor that binds DNA and produces the cGAMP second messenger from ATP and GTP. cGAMP binds to and activates STING, a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA. STING is ubiquitously expressed and found predominantly in the ER. Following activation, STING translocates with TBK1 to perinuclear endosomes. The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-κB, which leads to the induction of type I interferon and other immune response genes.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of cGAS protein.

Extra Notes: Western blot analysis of cGAS expression in Hela (A) whole cell lysates.

Bioworld Molecular Weight: ~ 64 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: C6orf150; Cyclic GMP-AMP synthase; cGAMP synthase; cGAS; h-cGAS; Mab-21 domain-containing protein 1

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human cGAS. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified