cGAS rabbit pAb - ES15063

cGAS rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15063-50, ES15063-100

Citations, Manuals and MSDS Available upon request.

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human M21D1 AA range: 35-85

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 115004

Human SWISS Prot NO: Q8N884

Subcellular Location: Nucleus. Chromosome. Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964). On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988). Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424). Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4, 5-bisphosphate (PtdIns (4, 5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Following detection of double-st

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