Product Description

CGRRH Polyclonal Antibody

Catalogue Numbers: BS61283-50, BS61283-100

Sizes: 50µl, 100µl

Alternative Name: Cell growth regulator with RING finger domain protein 1; Cell growth regulatory gene 19 protein; RING finger protein 197; CGRRF1; CGR19; RNF197

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q99675

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: CGR19 (Cell growth regulatory gene 19 protein), also known as Cell growth regulator with RING finger domain protein 1 and RING finger protein 197, is a 332 amino acid protein contains one RING-type zinc finger domain. CGR19 is ubiquitously expressed, with highest levels found in testis. It has been suggested that CGR19 plays a role in regulating the cell cycle because it inhibits growth in several cell lines. The gene encoding CGR19 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CGRRH polyclonal antibody detects endogenous levels of CGRRH protein.

Bioworld Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CGRRH polyclonal antibody at 1:500 dilution Lane 1: HEK293T whole cell lysate
Lane 2: 3T3 whole cell lysate Lane 3: H9C2 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CGRRH.

Conjugate: Unconjugated

Modification: Unmodified