Product Description

CH13L1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS60625-B-50, BS60625-B-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: P36222

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB: 1:2000~1:5000
IHC: 1:50~1:100

Background: YKL-40, also known as Chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein encoded by the CHI3L1 gene . Unlike other members of the chitinase-like protein family, YKL-40 is not an active chitinase. It is produced by activated macrophages, chondrocytes, neutrophils, and synovial cells. It is a pro-inflammatory molecule that contributes to the progression of many inflammatory diseases, including fibrosis, neurodegenerative disease, breast, lung, prostate, liver, bladder, colon, and other types of cancers. Levels of YKL-40 in serum and plasma in patients with various types of tumors have been reported to predict poor prognosis, and in some clinical assays YKL-40 is being used as a predictive biomarker of cancer outcome.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CH13L1 polyclonal antibody detects endogenous levels of CH13L1 protein.

Bioworld Molecular Weight: ~ 30-40kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CH13L1 polyclonal antibody at 1:2000 dilution
Lane 1: THP-1 whole cell lysate (40ug)
Lane 2: SHSY5Y whole cell lysate (40ug)
Lane 3: MCF-7 whole cell lysate (40ug)
Lane 4: Myla2059 whole cell lysate (40ug), Immunohistochemistry of paraffin-embedded Human stomach cancer using CH13L1 antibody at dilution of 1:50 (40x lens).

Alternative Name: Chitinase-3-like protein 1; 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40; CHI3L1

Immunogen: Synthetic peptide, corresponding to Human CH13L1.

Conjugate: Unconjugated

Modification: Unmodified