ChemR23 Polyclonal Antibody - BT-AP01755

ChemR23 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP01755-20, BT-AP01755-50, BT-AP01755-100

Citations, Manuals and MSDS Available upon request.

Background: The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine b receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chem-otactic peptide receptor. It also acts as a coreceptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands.

Research Areas: Signal Transduction

Target Protein: CMKLR1

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ChemR23 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 42322

UniProt Accession: Human: Q99788; Mouse: P97468; Rat: O35786

Synonyms: CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ

GeneID: Human: 1240; Mouse: 14747

Research Use Only