CHK1 Monoclonal Antibody - BT-MCA3955

CHK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3955-50, BT-MCA3955-100

Citations, Manuals and MSDS Available upon request.

Background: CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

Research Areas: Epigenetics and nuclear signaling, Cancer

Target Protein: CHK1

Applications: WB

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 2G1D5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CHK1

Immunogen: Purified recombinant fragment of CHK1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 56kDa

UniProt Accession: O14757

Synonyms: CHEK1

GeneID: 1111

Research Use Only