Chk2 (Phospho-Ser19) Rabbit Polyclonal Antibody - BT-AP07757

Chk2 (Phospho-Ser19) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07757-20, BT-AP07757-50, BT-AP07757-100

Citations, Manuals and MSDS Available upon request.

Background: In response to DNA damage and replication blocks| cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated| the encoded protein is known to inhibit CDC25C phosphatase| preventing entry into mitosis| and has been shown to stabilize the tumor suppressor protein p53| leading to cell cycle arrest in G1. In addition| this protein interacts with and phosphorylates BRCA1| allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome| a highly penetrant familial cancer phenotype usually associated with inherited mutati

Research Areas: Cancer; Epigenetics and nuclear signaling

Target Protein: CHEK2

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Chk2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O96017; Mouse: Q9Z265

Synonyms: Chk2;Ser19; Serine/threonine-protein kinase Chk2; EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2

GeneID: Human: 11200; Mouse: 50883

Research Use Only