Product Description

CHMP4B+CHMP4C Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65990-50, BS65990-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the chromatin-modifying protein/charged mμltivesicμlar body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into mμltivesicμlar endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circμlar scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of mμltivesicμlar bodies. Mutations in this gene resμlt in autosomal dominant posterior polar cataracts.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit

Host: Rabbit

Applications: IHC-P

Alternate Names: SNF7 homolog associated with Alix 3, C20orf178, Charged mμltivesicμlar body protein 4b, Charged mμltivesicμlar body protein 4c, CHMP 4B, CHMP 4C, CHMP4A, Chromatin modifying protein 4B, Chromatin modifying protein 4C, CTPP3, dJ553F4.4, hSnf7 2, hSnf7 3, hVps32, MGC22825, Shax1, Shax3, SNF7 2, SNF7 3, SNF7, Snf7 homologue associated with Alix 1, Vacuolar protein sorting associated protein 7 2, Vacuolar protein sorting associated protein 7 3.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C:101-200/224

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: CHMP4B+CHMP4C Polyclonal Antibody detects endogenous levels of CHMP4B+CHMP4C protein.

Molecular Weight: 25kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H444, Q96CF2

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only