Product Description

CIC Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60283-50, BS60283-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Capicua, also referred to as CIC, is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granμle cells and regμlate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medμlloblastoma, the most common form of perdiatric brain tumor arising from irregμlar growth of granμle cells.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Protein capicua homolog, CIC, KIAA0306

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human CIC.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CIC polyclonal antibody detects endogenous levels of CIC protein.

Molecular Weight: ~ 164 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96RK0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only