Product Description

CIITA Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67513-50, BS67513-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MHC class II (MHC-II) proteins play critical roles in cellμlar immune responses and their expression is mainly regμlated by the non-DNA binding transcription factor CIITA (MHC class II transactivator) . CIITA expression is upregμlated by IFN-γ and it in turn enchances MHC-II expression and represses collagen expression . CIITA has a limited number of transcriptional targets, most of which are involved in MHC-mediated antigen presentation . Mutations in the CIITA are associated with the hereditary immunodeficiency disease Bare Lymphocyte Syndrome (BLS) which is characterized by a nearly complete absence of MHC-II expression (also referred to as MHC-II deficiency).

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: MHC2TA, MHC class II transactivator, CIITA

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of CIITA protein.

Molecular Weight: ~ 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P33076

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only