Product Description

CIITA Polyclonal Antibody

Catalogue Numbers: BS67513-50, BS67513-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P33076

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: MHC class II (MHC-II) proteins play critical roles in cellular immune responses and their expression is mainly regulated by the non-DNA binding transcription factor CIITA (MHC class II transactivator) . CIITA expression is upregulated by IFN-γ and it in turn enchances MHC-II expression and represses collagen expression . CIITA has a limited number of transcriptional targets, most of which are involved in MHC-mediated antigen presentation . Mutations in the CIITA are associated with the hereditary immunodeficiency disease Bare Lymphocyte Syndrome (BLS) which is characterized by a nearly complete absence of MHC-II expression (also referred to as MHC-II deficiency).

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of CIITA protein.

Extra Notes: Western blot analysis of CIITA expression in Beas2B (A), Jurkat (B) whole cell lysates.

Bioworld Molecular Weight: ~ 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: MHC2TA; MHC class II transactivator; CIITA

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified