CIITA Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA23362-50, RA23362-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: class II major histocompatibility complex transactivator (CIITA) Homo sapiens This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardi Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Alternate Names: CIITA, MHC2TA, MHC class II transactivator, CIITA Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Molecular Weight: 123 Protein Molecular Weight (kDa): 123 Storage: -20°C/1 year Human Gene ID: 4261 Human SwissProt Number: P33076 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only