CIITA rabbit pAb - ES6242

CIITA rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6242-50, ES6242-100

Citations, Manuals and MSDS Available upon request.

Background: class II major histocompatibility complex transactivator (CIITA) Homo sapiens This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardi

Alternate Name: CIITA; MHC2TA; MHC class II transactivator; CIITA

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human CIITA. AA range:706-755

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 123kD

Human Gene ID: 4261

Human SWISS Prot NO: P33076

Subcellular Location: Nucleus. Nucleus, PML body. Recruited to PML body by PML.

Research Use Only