Product Description

CK-6A/B/C Monoclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-22038-60, E-AB-22038-120, E-AB-22038-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: Cytokeratin 6

Target Synonym: CK-6A; CK-6D; CK6A; CK6C; CK6D; Cytokeratin-6A; Cytokeratin-6D; K2C6A; K6A; K6C; K6D; keratin 6A; Keratin; Keratin; type II cytoskeletal 6A; Keratin-6A; Krt6a; KRT6C; KRT6D; type II cytoskeletal 6A; Type-II keratin Kb6

Research Areas: Cancer, Signal Transduction, Tags and Cell Markers

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human

Application: WB, IHC-p, IF

Isotype: IgG

Clonality: Monoclonal

Clone No.: Clone:3B6

UNIProt ID: P02538,P04259,P48668

Background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification Method: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300

Calculated MW: 60kDa

Observed MW: 56-60kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only