CK16 Mouse mAb - EM1056

CK16 Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1056-50, EM1056-100

Citations, Manuals and MSDS Available upon request.

Background: Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.

Alternate Name: Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK

Source: Mouse

Applications: IHC

Dilution: IHC 1:200

Reactivity: Human, Rat, Mouse

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 51kDa

Human Gene ID: 3868

Human SWISS Prot NO: P08779

Subcellular Location: Intermediate filament

Research Use Only