CK8 Monoclonal Antibody (8G8) - BT-MCA0023

CK8 Monoclonal Antibody (8G8)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0023-20, BT-MCA0023-50, BT-MCA0023-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Signal transduction; Cancer

Target Protein: KRT8

Applications: IF, ICC, WB, IHC-p

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Keratin type II cytoskeletal 8

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 53573

UniProt Accession: Human: P05787; Mouse: P11679; Rat: Q10758

Synonyms: KRT8; CYK8; Keratin; type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8

GeneID: Human: 3856; Mouse: 16691; Rat: 25626

Research Use Only