CKMT1 Monoclonal Antibody-MB12344

CKMT1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12344-50, MB12344-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P12532

Host: Mouse

Reactivity: Human, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CKMT1 in rat Brain, 293T and CHO-K1Lysates using CKMT1 antibody.

Bioworld Molecular Weight: Calculated MW: 47 kDa; Observed MW: 47 kDa

Specificity: IgG1

Alternative Name: CKMT; CKMT1; UMTCK; CKMT1A

Immunogen: Purified recombinant human CKMT1 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified