Product Description

Claudin 1 (R197) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1063-50, BS1063-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellμlar transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecμle (JAM). Claudins, which consist of four transmembrane domains and two extracellμlar loops, make up tigh junction strands. Emerging evidence suggests that the claudin family of proteins regμlates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellμlar transport through tight junctions.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Claudin-1, CLD1, ILVASC, SEMP1, Claudin1, CLDN1, UNQ481/PRO944

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-1.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Claudin 1 (R197) polyclonal antibody detects endogenous levels of Claudin 1 protein.

Molecular Weight: ~ 22 kDa

Pathway: Contribution of ECM and Cytoskeletal Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95832

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only