Claudin-10 (N217) Polyclonal Antibody-BS1064

Claudin-10 (N217) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1064-50, BS1064-100

Sizes: 50µl, 100µl

Swiss-Prot: P78369

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Claudin 10 (N217) polyclonal antibody detects endogenous levels of Claudin 10 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Claudin-10 (N217) pAb at 1:500 dilution
Lane 1: Hela whole cell lysate (40ug)
Lane 2: The Kidney tissue lysate of Mouse (40ug)
Lane 3: The Kidney tissue lysate of Rat (40ug)
Lane 4: K562 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Claudin-10 (N217) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Claudin 10; OSP-like protein; CLDN10

Immunogen: Synthetic peptide, corresponding to amino acids 185-230 of Human Claudin-10.

Conjugate: Unconjugated

Modification: Unmodified