Claudin-11 rabbit pAb - ES6450

Claudin-11 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6450-50, ES6450-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso

Alternate Name: CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 20kD

Human Gene ID: 5010

Human SWISS Prot NO: O75508

Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Research Use Only